Description

Estrone-16,16-D2 is a deuterium-labeled analog of the natural estrogen hormone estrone, specifically deuterated at the 16-position. This compound is a critical stable isotope-labeled internal standard used in quantitative mass spectrometry to ensure analytical accuracy and reliability. It is essential for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise measurement of endogenous hormone levels or related metabolites.

Application

• LC-MS/MS Internal Standard: Primary use as a deuterated internal standard for the accurate quantification of estrone and related estrogens in biological matrices via liquid chromatography-tandem mass spectrometry.
• Clinical Research & Diagnostics: Enables precise hormone profiling in studies of endocrine disorders, menopause, hormone-dependent cancers, and metabolic diseases.
• Pharmaceutical Development: Supports pharmacokinetic and bioanalytical studies for drug candidates targeting estrogen pathways, ensuring reliable data for regulatory submissions.
• Forensic & Doping Control: Used in anti-doping laboratories and forensic analysis to detect and confirm the presence of exogenous estrogens or anabolic steroids.
• Environmental Analysis: Aids in the trace-level detection and quantification of estrogenic compounds in environmental water samples.
• Metabolomics & Biomarker Discovery: Facilitates high-precision measurement in metabolic pathway studies for biomarker identification and validation.

Basic Information

Product Name	Estrone-16,16-D2
CAS No.	56588-58-0
Molecular Formula	C18H20D2O2
Molecular Weight	272.39 g/mol
Synonyms	Estrone-16,16-d2; 3-Hydroxy-1,3,5(10)-estratrien-17-one-16,16-d2; 16,16-Dideuteroestrone; [16,16-D2]-Estrone; Estrone-d2 (16,16); Deuterated Estrone; Estra-1,3,5(10)-trien-3-ol-17-one-16,16-d2; 1,3,5(10)-Estratrien-3-ol-17-one-16,16-d2
EINECS	Contact for details

Quality Control

Our Estrone-16,16-D2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity and isotopic enrichment, NMR for structural confirmation, and MS for identity verification. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and residual solvent levels is provided with every shipment to ensure compliance with research and analytical standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, storage at -20°C is recommended. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 99.0% (by HPLC area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.