Description

1-Methylcarbamoyl-5-Fluorouracil is a fluorinated pyrimidine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a key synthetic intermediate and a potential prodrug moiety, offering a pathway to modulate the biological activity and delivery of therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel anticancer and antiviral therapies, where precise chemical building blocks are essential for innovation.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel fluoropyrimidine-based anticancer agents and prodrugs.
• Anticancer Research: Investigated for its potential role in inhibiting thymidylate synthase, a key enzyme in DNA synthesis for rapidly dividing cells.
• Prodrug Development: Used in the design of prodrugs aimed at improving the selectivity and reducing the systemic toxicity of chemotherapeutic agents.
• Biochemical Research: Employed in studies exploring nucleotide metabolism and the mechanisms of action of fluorouracil analogs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	1-Methylcarbamoyl-5-Fluorouracil
CAS No.	56563-18-9
Molecular Formula	C6H6FN3O3
Molecular Weight	187.13 g/mol
Synonyms	5-Fluoro-1-(methylcarbamoyl)uracil; 1-(Methylcarbamoyl)-5-fluorouracil; 5-Fluoro-1-(N-methylcarbamoyl)uracil; 1-Methylcarbamoyl-5-fluoro-2,4(1H,3H)-pyrimidinedione; NSC 172755; Uracil, 5-fluoro-1-[(methylamino)carbonyl]-
EINECS	Contact for details

Quality Control

Our 1-Methylcarbamoyl-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term stability is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.