Description

3α,12α-Bis[(Trifluoroacetyl)Oxy]-5β-Cholan-24-Oic Acid is a high-purity, synthetic bile acid derivative, specifically a trifluoroacetylated cholic acid analog. This compound is a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily needed by pharmaceutical companies and contract research organizations (CROs) engaged in metabolic studies, drug discovery, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel bile acid analogs and steroidal drugs targeting metabolic pathways.
• Biochemical Research: Used as a reference standard and probe in studies of bile acid metabolism, liver function, and transporter proteins (e.g., ASBT, NTCP).
• Metabolite Synthesis: Employed in the preparation of specific metabolites for pharmacokinetic and toxicological profiling studies.
• Analytical Chemistry: Serves as a high-purity calibration standard for HPLC, LC-MS, and GC-MS analysis in bioanalytical laboratories.
• Drug Discovery: Utilized in screening assays and as a precursor for developing FXR (Farnesoid X receptor) modulators and other nuclear receptor ligands.
• Academic Research: Fundamental research tool in universities and institutes studying cholestasis, gallstone formation, and lipid digestion.

Basic Information

Product Name	3α,12α-Bis[(Trifluoroacetyl)Oxy]-5β-Cholan-24-Oic Acid
CAS No.	56438-17-6
Molecular Formula	C28H38F6O6
Molecular Weight	584.60 g/mol
Synonyms	3α,12α-Bis(trifluoroacetoxy)-5β-cholan-24-oic acid; 3α,12α-Di(trifluoroacetoxy)-5β-cholan-24-oic acid; 5β-Cholan-24-oic acid, 3α,12α-bis[(trifluoroacetyl)oxy]-; Cholic acid 3,12-bis(trifluoroacetate); 3α,12α-Di-O-trifluoroacetylcholic acid; Trifluoroacetyl cholic acid derivative; TFA-Cholic acid derivative
EINECS	Contact for details

Quality Control

Our 3α,12α-Bis[(Trifluoroacetyl)Oxy]-5β-Cholan-24-Oic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.