Description

Uridine 5'-(Phosphoimidazolate) is a chemically modified nucleotide analog, specifically an activated uridine derivative. This compound is a critical reagent in synthetic organic chemistry and biochemistry for the enzymatic and chemical synthesis of nucleoside polyphosphates and oligonucleotides. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and life science research sectors for nucleotide synthesis and biochemical studies.

Application

• Biochemical Research: As a key intermediate in the enzymatic synthesis of nucleoside triphosphates (NTPs) and dinucleoside polyphosphates.
• Pharmaceutical Development: For the synthesis of modified nucleotide prodrugs and active pharmaceutical ingredients (APIs) targeting viral and metabolic diseases.
• Oligonucleotide Synthesis: Serves as a building block or activator in the preparation of RNA and modified DNA strands for therapeutic and diagnostic applications.
• Enzymology Studies: Used as a substrate analog to study the mechanism of kinases, polymerases, and other nucleotide-dependent enzymes.
• Chemical Biology Probes: Enables the site-specific incorporation of labels or functional groups into nucleic acids for imaging and interaction studies.

Basic Information

Product Name	Uridine 5'-(Phosphoimidazolate)
CAS No.	56428-57-0
Molecular Formula	C12H15N4O9P
Molecular Weight	390.25 g/mol
Synonyms	Uridine 5'-phosphorimidazolate; 5'-Uridylic imidazolide; Imidazole, 1-(5'-uridylyl)-; P1-(5'-Uridyl)-P2-imidazolyl diphosphate; Uridine 5'-monophosphorimidazolidate; UMP-Imidazolidate; Activated Uridine Monophosphate
EINECS	Contact for details

Quality Control

Our Uridine 5'-(Phosphoimidazolate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducibility and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.