Description

4-Deoxy-4-[3-Hydroxy-2-(1-Hydroxyethyl)Pyrrolidin-1-Yl]Rifamycin is a key semi-synthetic derivative of the rifamycin class of antibiotics, valued for its potent antibacterial activity against Gram-positive organisms and mycobacteria. This compound serves as a critical intermediate in the synthesis of advanced rifamycin-based pharmaceuticals, enabling the development of next-generation treatments. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers focused on anti-tuberculosis and anti-infective drug development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of advanced rifamycin antibiotics, such as rifampicin and rifabutin analogs.
• Antibacterial Research: Used in microbiological and pharmacological research to study structure-activity relationships (SAR) and develop new anti-infective agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the manufacturing process for final drug substances targeting tuberculosis and other bacterial infections.
• Fine Chemical Synthesis: Employed in custom synthesis and process chemistry for creating novel compounds with modified biological profiles.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	4-Deoxy-4-[3-Hydroxy-2-(1-Hydroxyethyl)Pyrrolidin-1-Yl]Rifamycin
CAS No.	56411-51-9
Molecular Formula	C39H49N3O12
Molecular Weight	751.82 g/mol
Synonyms	4-Deoxy-4-[3-hydroxy-2-(1-hydroxyethyl)pyrrolidin-1-yl]rifamycin S; 4-Deoxy-4-(3-hydroxy-2-(1-hydroxyethyl)-1-pyrrolidinyl)rifamycin; Rifamycin Derivative 56411-51-9; 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin; 25-Deacetyl-3-[[(4-methyl-1-piperazinyl)imino]methyl]rifamycin SV; A semisynthetic derivative of rifamycin SV.
EINECS	Contact for details

Quality Control

Our 4-Deoxy-4-[3-Hydroxy-2-(1-Hydroxyethyl)Pyrrolidin-1-Yl]Rifamycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.