Description

Tetrahydro-11-Deoxycortisol 21-Glucuronide is a key conjugated metabolite of steroid hormones, specifically formed by the glucuronidation of tetrahydro-11-deoxycortisol. This compound is of significant value in biochemical research and diagnostic applications as a reference standard for the precise quantification and metabolic profiling of corticosteroids. It is primarily required by pharmaceutical R&D laboratories, clinical diagnostic manufacturers, and academic institutions engaged in endocrinology and metabolism studies.

Application

• Reference Standard for Analytical Chemistry: Used as a high-purity calibrant in LC-MS/MS, HPLC, and GC-MS methods for steroid hormone analysis.
• Clinical Diagnostics Development: Essential for developing and validating immunoassays and mass spectrometry-based tests to measure cortisol and related steroid metabolites in biological samples.
• Metabolic Pathway Research: Serves as a critical tool in studying Phase II metabolism (glucuronidation) of glucocorticoids and adrenal steroids.
• Pharmaceutical Impurity Profiling: Employed in the identification and quantification of potential glucuronidated metabolites during drug development for corticosteroid-based therapeutics.
• Endocrinology Studies: Used in research investigating disorders of the hypothalamic-pituitary-adrenal (HPA) axis, such as Cushing's syndrome and adrenal insufficiency.
• Biomarker Discovery: Acts as a candidate biomarker in research exploring steroid profiles for various physiological and pathological conditions.

Basic Information

Product Name	Tetrahydro-11-Deoxycortisol 21-Glucuronide
CAS No.	56162-38-0
Molecular Formula	C27H40O11
Molecular Weight	540.60 g/mol
Synonyms	THS-Glucuronide; 3α,17α,21-Trihydroxy-5β-pregnane-11,20-dione 21-Glucuronide; 5β-Tetrahydro-11-deoxycortisol 21-Glucuronide; 3α,17α,21-Trihydroxy-5β-pregnan-20-one 21-Glucuronide; Urocortisol Glucuronide; 11-Deoxycortisol Tetrahydro Metabolite Glucuronide; 5β-Pregnane-3α,17α,21-triol-11,20-dione 21-Glucuronide
EINECS	Contact for details

Quality Control

Our Tetrahydro-11-Deoxycortisol 21-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.