Description

(2R,3R)-2,3-Dimethoxysuccinic Acid Dimethyl Ester is a high-purity chiral building block and synthetic intermediate of significant importance in asymmetric synthesis. This compound matters because its defined stereochemistry provides a crucial scaffold for constructing complex molecules with precise three-dimensional control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and fine chemical industries for applications such as chiral ligand synthesis and the preparation of advanced pharmaceutical intermediates.

Application

• Chiral Auxiliary and Ligand Synthesis: Serves as a key precursor for the development of novel chiral catalysts and ligands used in enantioselective transformations.
• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly those requiring specific (R,R) stereochemistry.
• Asymmetric Synthesis: Used in stereocontrolled reactions, including aldol condensations and nucleophilic substitutions, to introduce chiral centers.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where optical purity is paramount.
• Academic and Industrial R&D: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	(2R,3R)-2,3-Dimethoxysuccinic Acid Dimethyl Ester
CAS No.	56145-21-2
Molecular Formula	C8H14O6
Molecular Weight	206.19 g/mol
Synonyms	Dimethyl (2R,3R)-2,3-Dimethoxysuccinate; (R,R)-Dimethyl 2,3-Dimethoxysuccinate; (2R,3R)-2,3-Dimethoxybutanedioic Acid Dimethyl Ester; (R,R)-Tartaric Acid Dimethyl Ether Dimethyl Ester; D-Dimethyl O,O'-Dimethyl-L-tartrate; (2R,3R)-Tartaric Acid Dimethyl Ether Dimethyl Ester; (R,R)-O,O'-Dimethyl Tartrate Dimethyl Ester
EINECS	Contact for details

Quality Control

Our (2R,3R)-2,3-Dimethoxysuccinic Acid Dimethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high optical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.