Description

5-Fluorouracil-1-Yl Acetic Acid Methyl Ester is a key fluorinated pyrimidine derivative and an important pharmaceutical intermediate. This compound is valued for its role in the synthesis of more complex molecules, particularly in the development of novel anticancer and antiviral agents. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in nucleoside chemistry and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of fluoropyrimidine-based anticancer drugs and other therapeutic nucleoside analogs.
• Anticancer Agent Research: Serves as a precursor for developing prodrugs and novel compounds targeting thymidylate synthase in oncology research.
• Biochemical Research: Used in studies involving DNA/RNA synthesis inhibition and mechanism-of-action investigations for fluorouracil derivatives.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized fluorinated organic molecules.
• Academic & Industrial R&D: A valuable reagent for universities and corporate R&D departments exploring new fluorination strategies and medicinal chemistry.

Basic Information

Product Name	5-Fluorouracil-1-Yl Acetic Acid Methyl Ester
CAS No.	56059-28-0
Molecular Formula	C8H9FN2O4
Molecular Weight	216.17 g/mol
Synonyms	Methyl 2-(5-Fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate; 1-Carboxymethyl-5-fluorouracil Methyl Ester; 5-FU-1-yl Acetic Acid Methyl Ester; 5-Fluorouracil-1-acetic Acid Methyl Ester; 1-(Methoxycarbonylmethyl)-5-fluorouracil; 5-Fluorouracil N1-Acetic Acid Methyl Ester; Methyl (5-Fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetate
EINECS	Contact for details

Quality Control

Our 5-Fluorouracil-1-Yl Acetic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.