Description

(3β,5α,12β,19α,20R)-2α,20-Cyclo-8,9-Secoaspidospermidine-3-Carboxylic Acid Methyl Ester is a complex, high-purity indole alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical advanced intermediate or reference standard for the development of novel therapeutic agents, particularly in oncology and neurological research. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in cutting-edge medicinal chemistry and natural product synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex indole-based drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new analogs with optimized efficacy and safety profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control, method development, and identification in API (Active Pharmaceutical Ingredient) manufacturing.
• Natural Product Synthesis: A valuable intermediate in the total or semi-synthesis of complex aspidosperma-type alkaloids and their derivatives.
• Biochemical Research: Employed in studies investigating the interaction of alkaloid structures with enzymes, receptors, or other biological targets.
• Process Chemistry Development: Used to optimize synthetic routes, improve yields, and scale up production processes for related active compounds.

Basic Information

Product Name	(3β,5α,12β,19α,20R)-2α,20-Cyclo-8,9-Secoaspidospermidine-3-Carboxylic Acid Methyl Ester
CAS No.	56053-31-7
Molecular Formula	C21H26N2O2
Molecular Weight	338.45 g/mol
Synonyms	2α,20-Cyclo-8,9-secoaspidospermidine-3-carboxylic acid methyl ester; Methyl (3β,5α,12β,19α,20R)-2α,20-cyclo-8,9-secoaspidospermidine-3-carboxylate; 8,9-Secoaspidospermidine-3-carboxylic acid methyl ester derivative; Aspidosperma alkaloid intermediate; Secoaspidospermidine methyl ester
EINECS	Contact for details

Quality Control

Our (3β,5α,12β,19α,20R)-2α,20-Cyclo-8,9-Secoaspidospermidine-3-Carboxylic Acid Methyl Ester is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure full traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under an inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.