Description

(3β,5α,12β,19α,20R)-6,7-Didehydro-2α,20-Cycloaspidospermidine-3-Methanol Acetate is a complex, high-purity indole alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical advanced intermediate or reference standard for the development of novel bioactive molecules. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in medicinal chemistry and natural product studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathways for novel therapeutic agents, particularly in oncology and neurological research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC, LC-MS, and NMR analysis.
• Natural Product Synthesis: Employed in the total or semi-synthesis of complex indole alkaloids and their analogues for biological screening.
• Biochemical Tool Compound: Utilized in vitro and in vivo studies to investigate specific biological pathways and mechanisms of action.
• Process Chemistry Development: Acts as a model compound for scaling up and optimizing synthetic routes under cGMP conditions for API manufacturing.

Basic Information

Product Name	(3β,5α,12β,19α,20R)-6,7-Didehydro-2α,20-Cycloaspidospermidine-3-Methanol Acetate
CAS No.	56053-25-9
Molecular Formula	C22H28N2O2
Molecular Weight	352.47 g/mol
Synonyms	2α,20-Cycloaspidospermidine-3-methanol, 6,7-didehydro-, acetate (ester), (3β,5α,12β,19α,20R)-; 6,7-Didehydro-2α,20-cycloaspidospermidine-3-methanol acetate; Tabersonine derivative; Vinca alkaloid analogue; 19αH-Tabersonine acetate; Aspidosperma alkaloid intermediate
EINECS	Contact for details

Quality Control

Our (3β,5α,12β,19α,20R)-6,7-Didehydro-2α,20-Cycloaspidospermidine-3-Methanol Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.