Description

Paracetamol Mercapturate is a key metabolite of the common analgesic and antipyretic drug, acetaminophen (paracetamol). This compound is of significant importance in toxicological and pharmacological research, serving as a critical biomarker for drug metabolism studies and liver function assessment. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers involved in developing analytical methods, conducting bioequivalence studies, and investigating drug-induced hepatotoxicity.

Application

• Biomarker in Pharmacokinetic Studies: Used as a reference standard to quantify paracetamol metabolism in plasma and urine samples.
• Toxicology Research: Essential for studying the metabolic pathways of acetaminophen, particularly its conjugation with glutathione, to understand mechanisms of liver injury.
• Analytical Method Development: Serves as a high-purity standard for calibrating HPLC, LC-MS, and GC-MS systems in bioanalytical laboratories.
• Diagnostic Kit Manufacturing: Employed in the production and quality control of clinical diagnostic kits designed to monitor drug metabolism or overdose.
• Regulatory Compliance Testing: Used by pharmaceutical companies to fulfill regulatory requirements for metabolite profiling and impurity characterization of paracetamol-based drug products.
• Academic Research: A vital tool in university and institutional research focused on cytochrome P450 enzyme activity and phase II conjugation reactions.

Basic Information

Product Name	Paracetamol Mercapturate
CAS No.	55748-93-1
Molecular Formula	C13H16N2O5S
Molecular Weight	312.34 g/mol
Synonyms	N-Acetyl-4-aminophenol Mercapturate; Acetaminophen Mercapturate; APAP Mercapturate; N-Acetyl-p-benzoquinone imine Glutathione Conjugate (Reduced); 5-(N-Acetyl-L-cystein-S-yl)acetaminophen; Paracetamol Glutathione Adduct (Mercapturic Acid Pathway); 2-Acetamido-5-(N-acetylcystein-S-yl)phenol
EINECS	Contact for details

Quality Control

Our Paracetamol Mercapturate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.