Description

Enocitabine is a synthetic nucleoside analog with significant pharmaceutical and research applications. This compound is valued for its role as a key intermediate and active pharmaceutical ingredient (API) in the development of antiviral and anticancer therapeutics. It is primarily utilized by pharmaceutical manufacturers, biotechnology research institutions, and academic laboratories engaged in drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Active Pharmaceutical Ingredient (API): Used in the formulation of investigational and approved medicinal products targeting specific viral infections and cancer types.
• Biochemical Research: Employed as a reference standard and tool compound in studies of DNA/RNA synthesis inhibition, enzyme kinetics, and cellular metabolism.
• Antiviral Agent Development: Investigated for its potential activity against a range of DNA viruses due to its mechanism of action as a DNA chain terminator.
• Oncology Research: Studied for its cytostatic effects and potential use in chemotherapy regimens, particularly for hematological malignancies.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of related nucleoside analogs.

Basic Information

Product Name	Enocitabine
CAS No.	55726-47-1
Molecular Formula	C9H12N4O4
Molecular Weight	240.22 g/mol
Synonyms	2'-Deoxy-2',2'-difluorocytidine; Gemcitabine Impurity C; Gemcitabine Related Compound C; 4-Amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2',2'-Difluoro-2'-deoxycytidine; LY-188011; NSC 613327; DFDC
EINECS	Contact for details

Quality Control

Our Enocitabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with cGMP and relevant pharmacopeial guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.