Description

N(4)-Palmitoyl Cytarabine is a lipophilic prodrug derivative of the nucleoside analog cytarabine, designed to enhance cellular uptake and bioavailability. This chemical modification is critical for improving the therapeutic efficacy and delivery profile of the parent compound in advanced pharmaceutical formulations. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology drug discovery and targeted prodrug synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and development of novel anticancer prodrugs and liposomal formulations.
• Oncology Research: Used in preclinical studies to investigate improved drug delivery mechanisms for leukemia and other cancers.
• Prodrug Synthesis: Acts as a model compound in medicinal chemistry for studying the structure-activity relationships of fatty acid-conjugated nucleosides.
• Bioconjugation Studies: Employed in developing targeted therapeutic agents by leveraging its lipophilic palmitoyl chain for membrane integration.
• Drug Delivery System Development: A component in the design of nanocarriers and sustained-release systems to enhance pharmacokinetic properties.

Basic Information

Product Name	N(4)-Palmitoyl Cytarabine
CAS No.	55726-45-9
Molecular Formula	C30H52N4O6
Molecular Weight	540.76 g/mol
Synonyms	1-β-D-Arabinofuranosylcytosine 4'-N-Palmitate; Cytarabine 4'-N-Palmitoyl Ester; N4-Palmitoyl-1-β-D-arabinofuranosylcytosine; Palmitoyl Cytarabine; Ara-C Palmitate; Cytosine Arabinoside 4-N-Palmitate; N-Palmitoyl Cytarabine; Liposomal Cytarabine Prodrug
EINECS	Contact for details

Quality Control

Our N(4)-Palmitoyl Cytarabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.