Description

(2α,3β,5α,6β)-6-Hydroxy-1-Methylaspidofractinine-3-Carboxylic Acid Methyl Ester is a high-purity, structurally complex alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a critical chiral building block and a potential pharmacophore for developing novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of complex natural products, medicinal chemistry programs, and the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex alkaloid-based drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to explore new biological activities.
• Natural Product Synthesis: Acts as a crucial intermediate in the total or semi-synthesis of complex aspidosperma and related indole alkaloids.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, or NMR for method development and quality control in research settings.
• Biochemical Research: Investigated for potential interactions with various biological targets and enzyme systems.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of advanced intermediates.

Basic Information

Product Name	(2α,3β,5α,6β)-6-Hydroxy-1-Methylaspidofractinine-3-Carboxylic Acid Methyl Ester
CAS No.	55724-63-5
Molecular Formula	C21H26N2O3
Molecular Weight	354.45 g/mol
Synonyms	6-Hydroxy-1-methylaspidofractinine-3-carboxylic acid methyl ester; Methyl (2α,3β,5α,6β)-6-hydroxy-1-methylaspidofractinine-3-carboxylate; 1-Methyl-6-hydroxyaspidofractinine-3-carboxylic acid methyl ester; Aspidofractinine-3-carboxylic acid, 6-hydroxy-1-methyl-, methyl ester, (2α,3β,5α,6β)-; 55724-63-5; Aspidosperma alkaloid derivative
EINECS	Contact for details

Quality Control

Our (2α,3β,5α,6β)-6-Hydroxy-1-Methylaspidofractinine-3-Carboxylic Acid Methyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.