Description

Poly(Deoxyadenylic-Deoxycytidylic)-Poly(Deoxyguanylic-Thymidylic) Acid Sodium Salt is a synthetic, double-stranded alternating copolymer of deoxyribonucleotides, widely utilized as a defined nucleic acid substrate in biochemical research. This compound matters as a critical tool for studying DNA-protein interactions, enzyme kinetics, and nucleic acid structure due to its predictable and uniform sequence. It is primarily needed by biotechnology and pharmaceutical R&D laboratories, academic research institutions, and diagnostic developers for applications in molecular biology and enzymology.

Application

• Enzyme Substrate & Assay Development: Acts as a defined substrate for DNA polymerases, nucleases, helicases, and topoisomerases in kinetic and mechanistic studies.
• DNA-Protein Interaction Studies: Used in electrophoretic mobility shift assays (EMSAs), footprinting, and other techniques to investigate binding specificity and affinity of transcription factors and other DNA-binding proteins.
• Molecular Biology Research: Serves as a template or primer in controlled experiments to understand replication, transcription, and repair mechanisms.
• Biophysical Characterization: Employed in spectroscopic studies (e.g., UV, CD) to analyze DNA duplex stability, conformation, and ligand interactions under various conditions.
• Diagnostic & Sensor Development: Can be used as a component in the development of biosensors or diagnostic assays that require specific, synthetic DNA sequences.
• Quality Control & Standardization: Functions as a reference material or control in nucleic acid-based testing and sequencing platforms.

Basic Information

Product Name	Poly(Deoxyadenylic-Deoxycytidylic)-Poly(Deoxyguanylic-Thymidylic) Acid Sodium Salt
CAS No.	55684-99-6
Molecular Formula	Contact for details
Molecular Weight	Variable (Polymer)
Synonyms	Poly(dA-dC)-Poly(dG-dT); Poly(dA-dC)·Poly(dG-dT); Poly(deoxyadenylate-deoxycytidylate)-Poly(deoxyguanylate-thymidylate); Alternating Copolymer dA-dC : dG-dT; Synthetic Double-Stranded DNA Copolymer; Poly(dA-dC):Poly(dG-dT) Sodium Salt; DNA Copolymer (Alternating AC/GT); Poly(dA-dC)•Poly(dG-dT)
EINECS	Contact for details

Quality Control

Our Poly(Deoxyadenylic-Deoxycytidylic)-Poly(Deoxyguanylic-Thymidylic) Acid Sodium Salt is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and performance in sensitive research applications. Each lot is characterized for sequence integrity, duplex formation, and purity. A comprehensive Certificate of Analysis (COA) detailing specifications such as absorbance ratios, melting temperature (Tm), and endotoxin levels is provided to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White or off-white fibrous solid or lyophilized powder
Identification (UV)	Characteristic absorbance spectrum consistent with double-stranded DNA
A260/A280 Ratio	1.8 - 2.0 (in 10 mM Tris-HCl, pH 8.0)
Hyperchromicity	> 30% (upon thermal denaturation)
Assay (Purity)	> 95% (by HPLC or PAGE)
Endotoxin	< 1.0 EU/mg (where specified)
Solubility	Soluble in aqueous buffers (e.g., Tris-EDTA, saline sodium citrate)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.