Description

6-Chloro-9 β-D-Ribofuranosylpurine-5'-Triphosphate is a chemically modified nucleoside triphosphate analog, a critical building block for advanced biochemical research and development. This compound is essential for studying and manipulating nucleic acid structure and function, particularly in enzymatic reactions involving polymerases. It is primarily utilized by researchers and developers in the fields of molecular biology, enzymology, and pharmaceutical discovery for applications such as probe synthesis and mechanistic studies.

Application

• Substrate for DNA/RNA Polymerases: Used as a modified nucleotide triphosphate (NTP) in enzymatic synthesis to incorporate chloropurine bases into oligonucleotides.
• Biochemical Probe Development: Serves as a key reagent for creating labeled or functionally modified nucleic acid probes for diagnostic and research applications.
• Enzyme Kinetics and Mechanism Studies: Employed to investigate the specificity and catalytic mechanisms of various nucleotidyltransferases and kinases.
• Antiviral and Anticancer Research: Acts as a precursor or analog in the development and screening of nucleoside-based therapeutic agents.
• Structural Biology: Used in X-ray crystallography or NMR studies to understand nucleic acid-protein interactions with modified bases.
• Next-Generation Sequencing (NGS): Potential utility in the development of novel sequencing chemistries or as a chain-terminating analog.

Basic Information

Product Name	6-Chloro-9 β-D-Ribofuranosylpurine-5'-Triphosphate
CAS No.	55673-61-5
Molecular Formula	C10H15ClN5O13P3
Molecular Weight	565.62 g/mol
Synonyms	6-Chloro-9-β-D-ribofuranosylpurine-5'-triphosphate; 6-Chloropurine riboside 5'-triphosphate; 6-Chloro-9-β-D-ribofuranosyl-9H-purine-5'-triphosphate; 6-Cl-Purine riboside triphosphate; 6-Chloropurine ribonucleoside triphosphate; 6-Chloro-9-(β-D-ribofuranosyl)purine-5'-triphosphate; 6-Chloro-9-(β-D-ribofuranosyl)-9H-purine-5'-triphosphate; 6-Cl-PurRTP
EINECS	Contact for details

Quality Control

Our 6-Chloro-9 β-D-Ribofuranosylpurine-5'-Triphosphate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for sensitive biochemical research. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol
Biological Activity	Suitable for use as a polymerase substrate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.