Description

5-Iodocytidylyl-(3'-5')-Guanosine is a chemically modified dinucleotide, a critical building block in oligonucleotide synthesis and biochemical research. This compound is essential for introducing specific modifications into nucleic acid sequences, enabling advanced studies in molecular biology, diagnostics, and therapeutic development. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on antisense technology, probe development, and structural biology.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Biochemical Research: Used as a substrate or intermediate in enzymatic studies, particularly those involving polymerases and nucleases.
• Probe Development: Incorporated into labeled probes for fluorescence in situ hybridization (FISH) and other detection assays due to the iodine moiety.
• Antisense & Therapeutic Development: A vital component in creating modified oligonucleotides for potential therapeutic applications targeting gene expression.
• Structural Studies: Employed in X-ray crystallography and NMR spectroscopy to investigate nucleic acid structure and function.
• Diagnostic Assay Development: Used in the design and manufacture of diagnostic kits requiring specific nucleotide modifications for enhanced specificity.

Basic Information

Product Name	5-Iodocytidylyl-(3'-5')-Guanosine
CAS No.	55628-64-3
Molecular Formula	C19H23IN8O12P
Molecular Weight	722.21 g/mol
Synonyms	5-Iodo-CpG; 5-Iodocytidylyl(3'→5')guanosine; Cytidylyl-(3'-5')-guanosine, 5-iodo-; 5-I-3',5'-cG; 5-Iodocytidine(5')-phosphoryl-(3')guanosine; 5-Iodocytidylyl-(3',5')-Guanosine; 5-Iodo-Cytidine-Guanosine Dinucleotide; Iodinated CpG Dinucleotide
EINECS	Contact for details

Quality Control

Our 5-Iodocytidylyl-(3'-5')-Guanosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and MS and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.