Description

3(S)-Oxidosqualene is a key enzymatic intermediate in the biosynthesis of sterols and triterpenes, representing a critical branch point in the mevalonate pathway. Its high purity and defined stereochemistry are essential for research into cholesterol metabolism, enzyme inhibition studies, and the development of novel therapeutic agents. This compound is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-value fine chemicals and active pharmaceutical ingredients (APIs).

Application

• Enzymology Research: Substrate for studying the enzyme 2,3-oxidosqualene cyclase (lanosterol synthase) and related cyclases.
• Drug Discovery: A critical intermediate for screening and developing inhibitors targeting cholesterol biosynthesis, with potential applications in treating hypercholesterolemia.
• Biochemical Pathway Analysis: Used to investigate the sterol and triterpenoid biosynthetic pathways in eukaryotes and plants.
• Reference Standard: Serves as an analytical standard for HPLC, LC-MS, or NMR in quality control and metabolic studies.
• Synthetic Chemistry: A chiral building block for the semi-synthesis of complex natural products and sterol analogs.

Basic Information

Product Name	3(S)-Oxidosqualene
CAS No.	54910-48-4
Molecular Formula	C30H50O
Molecular Weight	426.72 g/mol
Synonyms	(3S)-2,3-Epoxysqualene; (S)-2,3-Epoxysqualene; 3(S)-2,3-Epoxysqualene; (3S)-Oxidosqualene; Squalene 2,3-epoxide, (3S)-; Squalene-2,3(S)-epoxide; 2,3(S)-Epoxysqualene; Lanosterol synthase substrate
EINECS	Contact for details

Quality Control

Our 3(S)-Oxidosqualene is manufactured under strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), chiral purity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (3S-isomer)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.