Description

(S)-(-)-4-tert-Butyl-2-Oxazolidinone is a high-value, enantiomerically pure chiral auxiliary and building block widely used in asymmetric synthesis. Its core value lies in enabling the stereoselective construction of complex molecules, which is critical for producing single-isomer active pharmaceutical ingredients (APIs) and advanced materials. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity chiral reagents to control reaction outcomes and ensure product efficacy.

Application

• As a chiral auxiliary in Evans-type asymmetric alkylation, aldol, and Michael addition reactions.
• Key building block for the synthesis of enantiomerically pure β-amino acids and other pharmacologically active compounds.
• Intermediate in the development of novel catalysts and ligands for asymmetric hydrogenation and other transition metal-catalyzed processes.
• Used in academic and industrial research for method development in stereoselective organic synthesis.
• Production of high-value fine chemicals and advanced materials where precise stereochemistry is required.
• Potential use in the synthesis of peptides and peptidomimetics with defined three-dimensional structures.

Basic Information

Product Name	(S)-(-)-4-tert-Butyl-2-Oxazolidinone
CAS No.	54705-42-9
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(S)-4-(tert-Butyl)-1,3-oxazolidin-2-one; (S)-(-)-4-tert-Butyl-2-oxazolidinone; (S)-4-tert-Butyloxazolidin-2-one; (S)-N-tert-Butyloxazolidinone; Evans Chiral Auxiliary (tert-Butyl variant); (S)-tert-Butyl Oxazolidinone; (S)-4-(1,1-Dimethylethyl)-2-oxazolidinone; (S)-4-(tert-Butyl)oxazolidin-2-one
EINECS	Contact for details

Quality Control

Our (S)-(-)-4-tert-Butyl-2-Oxazolidinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for asymmetric synthesis applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and identity confirmation. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	86 - 90 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.