Description

1-Methylsulfonyl-5-Fluorouracil is a fluorinated pyrimidine derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. This high-purity building block is critical for research and development in medicinal chemistry, enabling the creation of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology and antiviral drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel fluoropyrimidine-based anticancer and antiviral agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a key starting material for scaling up the production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating nucleotide metabolism and the mechanism of action of fluorouracil analogs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1-Methylsulfonyl-5-Fluorouracil
CAS No.	54391-00-3
Molecular Formula	C6H5FN2O4S
Molecular Weight	220.18 g/mol
Synonyms	5-Fluoro-1-(methylsulfonyl)uracil; 1-(Methylsulfonyl)-5-fluorouracil; 5-Fluoro-1-methanesulfonyluracil; MS-5-FU; 1-Methanesulfonyl-5-fluorouracil; 5-Fluorouracil-1-methylsulfone; 54391-00-3
EINECS	Contact for details

Quality Control

Our 1-Methylsulfonyl-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.