Description

Decitabine is a potent and specific DNA methyltransferase inhibitor, widely recognized for its role in epigenetic regulation. This compound is critical for research and development in oncology and hematology, offering a targeted mechanism to reactivate silenced tumor suppressor genes. It is primarily utilized by pharmaceutical manufacturers, academic research institutions, and clinical laboratories engaged in cancer therapy development and cellular biology studies.

Application

• Oncological Therapeutics: Active pharmaceutical ingredient (API) in formulations for the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
• Biomedical Research: A key tool for studying DNA methylation, epigenetic reprogramming, and gene expression regulation in cellular and animal models.
• Drug Discovery & Development: Used in high-throughput screening and preclinical studies to identify and validate novel epigenetic targets and combination therapies.
• Clinical Diagnostics: Employed in research settings to understand patient response mechanisms and develop companion diagnostic assays.
• Cell Culture & Differentiation Studies: Applied in *in vitro* studies to induce differentiation and alter the phenotype of various cell lines.

Basic Information

Product Name	Decitabine
CAS No.	54199-94-9
Molecular Formula	C8H12N4O4
Molecular Weight	228.21 g/mol
Synonyms	5-Aza-2'-deoxycytidine; 5-Aza-dCyd; Dacogen (trade name); 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; NSC 127716; Dezocitidine; 5-Aza-CdR
EINECS	Contact for details

Quality Control

Our Decitabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent controls for related substances and residual solvents. Certificates of Analysis (COA) detailing full specifications are provided to ensure compliance with pharmaceutical research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.