Description

2-Hydroxy Imipramine B-D-Glucuronide is a key glucuronide metabolite of the tricyclic antidepressant imipramine. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development, metabolite identification, and regulatory safety testing.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of imipramine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance rates, and bioavailability of imipramine in preclinical and clinical research.
• Bioanalytical Method Development: Essential for developing and validating sensitive LC-MS/MS or HPLC-UV methods for therapeutic drug monitoring (TDM) and toxicology screening.
• Impurity Profiling: Employed as a specified impurity standard in the quality control of imipramine active pharmaceutical ingredient (API) to ensure product safety and compliance with ICH guidelines.
• Clinical Research: Supports studies on inter-individual variability in drug metabolism and potential drug-drug interactions involving imipramine.

Basic Information

Item	Details
Product Name	2-Hydroxy Imipramine B-D-Glucuronide
CAS No.	54190-76-0
Molecular Formula	C25H31N3O7
Molecular Weight	485.53 g/mol
Synonyms	2-Hydroxyimipramine Glucuronide; 2-OH-Imipramine Glucuronide; Imipramine Metabolite Glucuronide; 2-Hydroxyimipramine β-D-Glucuronide; 10,11-Dihydro-5-[3-(methylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepin-2-yl β-D-Glucopyranosiduronic Acid; Imipramine-2-O-β-D-Glucuronide; N-Desmethylimipramine-2-O-β-D-Glucuronide (related metabolite)
EINECS	Contact for details

Quality Control

Our 2-Hydroxy Imipramine B-D-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.