Description

Dodecylphosphocholine is a high-purity synthetic phospholipid analog, also known as Fos-Choline-12. This compound serves as a critical, mild non-ionic detergent for the solubilization and stabilization of membrane proteins in biochemical research. It is essential for scientists and manufacturers in structural biology, drug discovery, and biotechnology who require reliable, high-quality reagents for challenging protein purification workflows. Dodecylphosphocholine CAS NO 53949-18-1 is a cornerstone reagent for creating stable, functional membrane protein samples.

Application

• Membrane Protein Solubilization: Primary application for extracting integral membrane proteins from lipid bilayers while maintaining native structure and function.
• Protein Crystallography: Used to create stable, homogeneous protein-detergent complexes suitable for crystallization and X-ray diffraction studies.
• Biophysical Analysis: Essential for preparing samples for techniques like NMR spectroscopy, cryo-electron microscopy (cryo-EM), and surface plasmon resonance (SPR).
• Drug Discovery Assays: Utilized in functional assays for G-protein-coupled receptors (GPCRs), ion channels, and other membrane-bound drug targets.
• Liposome and Nanodisc Formation: Acts as a component or starting material for constructing model membrane systems and membrane scaffolding proteins.
• Cell Lysis: Effective mild detergent for gentle cell membrane disruption in specific biochemical preparations.

Basic Information

Item	Detail
Product Name	Dodecylphosphocholine
CAS No.	53949-18-1
Molecular Formula	C17H38NO4P
Molecular Weight	351.46 g/mol
Synonyms	Fos-Choline-12; 1-Dodecanoyl-2-hydroxy-sn-glycero-3-phosphocholine (lyso derivative); DPC; Laurylphosphocholine; 12:0 Lyso PC; 1-Lauroyl-2-hydroxy-sn-glycero-3-phosphocholine; n-Dodecylphosphocholine; Lyso-PC(12:0/0:0)
EINECS	Contact for details

Quality Control

Our Dodecylphosphocholine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurities. We adhere to rigorous in-house specifications aligned with the needs of the life science and pharmaceutical industries. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.