Description

Pentostatin is a potent purine nucleoside analog and a highly specific inhibitor of adenosine deaminase (ADA). This mechanism of action is critical for disrupting DNA synthesis and inducing apoptosis in susceptible cells, making it a valuable therapeutic agent. It is primarily utilized in the pharmaceutical industry for the development and manufacture of targeted oncology treatments. Pentostatin CAS NO 53910-25-1 is supplied to meet the stringent requirements of research, development, and commercial pharmaceutical production.

Application

• Oncological Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) for the treatment of specific lymphoproliferative disorders, most notably hairy cell leukemia.
• Biomedical Research: A critical research tool for studying adenosine deaminase deficiency, immune system regulation, and mechanisms of purine metabolism.
• Preclinical & Clinical Development: Used in the formulation and testing of new chemotherapeutic agents and combination therapies within clinical trials.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	Pentostatin
CAS No.	53910-25-1
Molecular Formula	C11H16N4O4
Molecular Weight	268.27 g/mol
Synonyms	2'-Deoxycoformycin; dCF; (R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol; CI-825; PD-81565; NSC-218321; Pentostatinum; Nipent® (brand name)
EINECS	Contact for details

Quality Control

Our Pentostatin is manufactured under strict quality systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP (current Good Manufacturing Practice) guidelines and relevant pharmacopeial standards (e.g., USP) for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.