Description

6-β-Hydroxycortisol Sulfate is a significant sulfated metabolite of cortisol, a primary glucocorticoid hormone. This compound is crucial for researchers investigating steroid metabolism, endocrine pathways, and the development of analytical standards for clinical diagnostics. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and manufacturers of in-vitro diagnostic (IVD) reagents and reference materials.

Application

• Biomarker Research: Used as a reference standard in the study of cortisol metabolism and HPA axis activity for clinical research.
• Diagnostic Assay Development: Serves as a critical calibrant and quality control material in the production of immunoassays and LC-MS/MS kits for hormone analysis.
• Pharmaceutical Metabolite Profiling: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to identify and quantify drug-related metabolites.
• Endocrinology Studies: A key analyte in research focused on stress response, Cushing's syndrome, adrenal disorders, and metabolic diseases.
• Reference Material Production: Used by certified reference material (CRM) producers to create traceable standards for laboratory accreditation and method validation.

Basic Information

Product Name	6-β-Hydroxycortisol Sulfate
CAS No.	53587-06-7
Molecular Formula	C21H30O9S
Molecular Weight	458.52 g/mol
Synonyms	6β-Hydroxycortisol 21-Sulfate; Cortisol 6β-sulfate; 6β-Hydroxycortisol Sulfate; 11β,17α,21-Trihydroxy-6β-hydroxypregn-4-ene-3,20-dione 21-Sulfate; (6β,11β,17α)-17,21-Dihydroxypregn-4-ene-3,11,20-trione 21-Sulfate; 6β-Hydroxycortisol 21-(Hydrogen Sulfate); 6β-OH-Cortisol Sulfate
EINECS	Contact for details

Quality Control

Our 6-β-Hydroxycortisol Sulfate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.