Description

Oxoprenolol Glucuronide is a key metabolite of the β-blocker oxprenolol, formed via glucuronidation in the liver. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a critical reference standard for laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors, enabling accurate quantification and characterization of oxprenolol and its metabolic pathways.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of oxprenolol and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic fate, clearance mechanisms, and bioavailability of oxprenolol in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a critical calibrant and quality control sample in developing and validating HPLC, LC-MS, and LC-MS/MS assays.
• Pharmacology Research: Aids in understanding the activity and potential interactions of oxprenolol metabolites.
• Impurity Profiling: Used to identify and quantify glucuronide-related impurities in oxprenolol active pharmaceutical ingredient (API) batches.
• Toxicology Studies: Employed in studies assessing the safety and metabolic profile of oxprenolol.

Basic Information

Product Name	Oxoprenolol Glucuronide
CAS No.	53564-66-2
Molecular Formula	C23H35NO9
Molecular Weight	469.53 g/mol
Synonyms	Oxprenolol Glucuronide; 1-[(1-Methylethyl)amino]-3-[2-(allyloxy)phenoxy]-2-propanol Glucuronide; Oxprenolol O-Glucuronide; Oxprenolol β-D-Glucuronide; (RS)-Oxprenolol Glucuronide; (±)-Oxprenolol Glucuronide; Oxprenolol Acid Glucuronide
EINECS	Contact for details

Quality Control

Every batch of Oxoprenolol Glucuronide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.