Description

(1S,2R,4S)-2-Ethyl-1,2,3,4,6,11-Hexahydro-2,4,5,7-Tetrahydroxy-6,11-Dioxo-1-Naphthacenecarboxylic Acid Methyl Ester is a high-purity, complex tetracycline-class intermediate with significant synthetic utility. This compound is valued for its role as a critical building block in the synthesis of advanced pharmaceutical agents, particularly novel antibiotics and research compounds. It is essential for R&D laboratories, process development chemists, and manufacturers in the fine chemical and active pharmaceutical ingredient (API) sectors seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel tetracycline-derived antibiotics and other therapeutic agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new antimicrobial compounds.
• Process Chemistry: Serves as a standard or starting material for optimizing scalable synthetic routes in API manufacturing.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Chemical Synthesis: Utilized in organic synthesis for constructing complex polycyclic molecular frameworks due to its functionalized naphthacene core.

Basic Information

Product Name	(1S,2R,4S)-2-Ethyl-1,2,3,4,6,11-Hexahydro-2,4,5,7-Tetrahydroxy-6,11-Dioxo-1-Naphthacenecarboxylic Acid Methyl Ester
CAS No.	53526-61-7
Molecular Formula	C₂₂H₂₂O₉
Molecular Weight	430.41 g/mol
Synonyms	Methyl (1S,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,4,5,7-tetrahydroxy-6,11-dioxo-1-naphthacenecarboxylate; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline methyl ester; Anhydrotetracycline methyl ester derivative; 2-Ethyl-1,2,3,4,6,11-hexahydro-2,4,5,7-tetrahydroxy-6,11-dioxo-1-naphthacenecarboxylic acid methyl ester; ATC methyl ester
EINECS	Contact for details

Quality Control

Our (1S,2R,4S)-2-Ethyl-1,2,3,4,6,11-Hexahydro-2,4,5,7-Tetrahydroxy-6,11-Dioxo-1-Naphthacenecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and synthesis. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.