Description

n-[p-[[(2,4-Diaminopteridin-7-Yl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid is a high-purity pharmaceutical intermediate and reference standard of significant importance in medicinal chemistry and oncology research. This compound, also known as a key derivative in the folate analog family, matters for its role in the development and quality control of targeted therapeutic agents. It is primarily needed by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in the synthesis and analysis of antimetabolite drugs, where precise chemical structure and purity are critical for efficacy and safety studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel folate antagonist compounds for therapeutic development.
• Reference Standard: Used in analytical laboratories for the identification, assay, and impurity profiling of related active pharmaceutical ingredients (APIs) via HPLC, LC-MS, or NMR.
• Biochemical Research: Employed in studies investigating enzyme inhibition mechanisms, particularly targeting dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Oncology Drug Discovery: A key precursor in research programs focused on developing next-generation antimetabolites for cancer chemotherapy.
• Quality Control & Validation: Essential for method development and validation in QC/QA departments to ensure the purity and consistency of final drug products.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and chemical biology.

Basic Information

Product Name	n-[p-[[(2,4-Diaminopteridin-7-Yl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
CAS No.	52980-66-2
Molecular Formula	C₂₀H₂₄N₈O₅
Molecular Weight	456.46 g/mol
Synonyms	N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid; 4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoic acid (2S)-2-[(4-aminophenyl)formamido]pentanedioic acid (incorrect but common misconstruction); L-Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; Pteroic acid derivative; Folate analog intermediate; 2,4-Diaminopteridine-glutamate conjugate; PT523 related compound
EINECS	Contact for details

Quality Control

Our n-[p-[[(2,4-Diaminopteridin-7-Yl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.