Description

Nicotinamide-8-Bromoadenine Dinucleotide is a chemically modified coenzyme analog, specifically a brominated derivative of NAD+. This compound is of significant value in biochemical research as a potent inhibitor and mechanistic probe for NAD+-dependent enzymes, particularly dehydrogenases. It is primarily utilized by research scientists and pharmaceutical developers in enzymology studies, drug discovery programs, and the investigation of metabolic pathways.

Application

• Enzyme Inhibition Studies: Acts as a specific active-site inhibitor for NAD+-dependent dehydrogenases, aiding in mechanistic elucidation.
• Drug Discovery & Development: Serves as a key biochemical tool for screening and validating novel therapeutics targeting NAD+-utilizing enzymes.
• Metabolic Pathway Research: Used to probe and modulate critical cellular processes like glycolysis, the Krebs cycle, and oxidative phosphorylation.
• Structural Biology: Employed in X-ray crystallography and other techniques to study enzyme-cofactor binding interactions.
• Biochemical Assay Development: Utilized as a reference standard or control in developing high-throughput screening assays.
• Academic Research: Fundamental tool in university and institutional labs for studying enzyme kinetics and cofactor specificity.

Basic Information

Product Name	Nicotinamide-8-Bromoadenine Dinucleotide
CAS No.	52977-37-4
Molecular Formula	C21H26BrN7O14P2
Molecular Weight	766.33 g/mol
Synonyms	8-Bromo-NAD+; 8-Bromoadenine NAD+; β-Nicotinamide adenine dinucleotide, 8-bromo-; 8-Br-NAD; NAD+ 8-bromo analog; 8-Bromonicotinamide adenine dinucleotide; Brominated NAD coenzyme
EINECS	Contact for details

Quality Control

Our Nicotinamide-8-Bromoadenine Dinucleotide is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for reliable research outcomes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research and development with materials suitable for analytical and biochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store desiccated under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.