Description

Casein Kinase II is a ubiquitous and highly conserved serine/threonine protein kinase essential for numerous cellular processes. Its broad substrate specificity and constitutive activity make it a critical regulatory enzyme in signal transduction pathways. This product is primarily utilized by researchers in biochemical and pharmaceutical R&D for studying cell cycle regulation, transcription, and as a tool in drug discovery for targeting kinase-related diseases.

Application

• Biochemical Research: A fundamental tool for in vitro phosphorylation studies, substrate identification, and enzymatic characterization.
• Drug Discovery & Screening: Used in high-throughput assays to identify and validate novel kinase inhibitors for cancer, neurodegenerative, and inflammatory diseases.
• Signal Transduction Studies: Essential for investigating pathways involving cell growth, proliferation, and apoptosis.
• Diagnostic Development: Serves as a component in developing assays for monitoring kinase activity in clinical samples.
• Academic Research: Key reagent for studies in molecular biology, cell biology, and genetics focusing on post-translational modification.

Basic Information

Product Name	Casein Kinase II
CAS No.	52660-18-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CK2; Casein Kinase 2; CKII; Casein Kinase II Alpha; CSNK2A1; Casein Kinase II Catalytic Subunit Alpha; Protein Kinase CK2; Phosvitin Kinase
EINECS	Contact for details

Quality Control

Our Casein Kinase II is produced and tested under stringent conditions to ensure high purity, specific activity, and batch-to-batch consistency. Each lot undergoes comprehensive analysis, including activity assays and purity verification. Certificates of Analysis (COA) detailing specific activity, purity, and storage buffer composition are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Purity (SDS-PAGE)	> 90%
Specific Activity	> 500 units/mg protein
Identification (Activity)	Phosphorylates standard peptide substrate
Buffer Composition	Specified in COA
Endotoxin Level	< 1.0 EU/μg (for research-grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.