Description

H-Tyr-Pna is a specialized peptide derivative and a key protected amino acid building block used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for constructing complex peptides and peptidomimetics. It is primarily utilized in pharmaceutical R&D, particularly in the development of active pharmaceutical ingredients (APIs) and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the solid-phase and solution-phase synthesis of therapeutic peptides.
• Biochemical Research: Used in proteomics and enzymology studies as a substrate or inhibitor analog for tyrosine-specific enzymes.
• API Development: Employed in the research and scale-up synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Peptidomimetic Design: Acts as a precursor for creating non-natural peptide analogs with enhanced stability and bioavailability.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	H-Tyr-Pna
CAS No.	52551-07-2
Molecular Formula	C16H17N3O4
Molecular Weight	315.33 g/mol
Synonyms	N-(4-Nitrophenyl)-L-tyrosinamide; L-Tyrosine, N-(4-nitrophenyl)-; H-Tyr-pNA; Tyrosine p-nitroanilide; N-(p-Nitrophenyl)-L-tyrosinamide; N4-(p-Nitrophenyl)-L-tyrosinamide; Substrate for Chymotrypsin; 52551-07-2
EINECS	Contact for details

Quality Control

Our H-Tyr-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.