Description

10-Deazaaminopterin is a synthetic analog of folic acid, representing a significant compound in medicinal chemistry research. Its core value lies in its role as a potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folate metabolism and nucleotide synthesis. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, autoimmune diseases, and the development of novel antifolate therapeutics. The product is supplied as a high-purity reference standard and research chemical.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel antifolate drugs.
• Oncology Studies: Used in biochemical and cellular assays to study DHFR inhibition mechanisms and evaluate potential chemotherapeutic agents targeting rapidly dividing cells.
• Biochemical Research: Employed as a selective tool compound to investigate folate metabolism pathways, nucleotide biosynthesis, and cellular proliferation in academic and industrial laboratories.
• Enzyme Inhibition Assays: Acts as a potent, well-characterized inhibitor for validating DHFR enzyme activity assays and high-throughput screening (HTS) platforms.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and toxicology studies during the early stages of drug candidate evaluation.

Basic Information

Product Name	10-Deazaaminopterin
CAS No.	52454-37-2
Molecular Formula	C₁₉H₂₁N₇O₅
Molecular Weight	427.42 g/mol
Synonyms	10-Deaza-aminopterin; 10-DAM; NSC 127755; 4-Amino-10-deazapteroylglutamic acid; 4-Amino-4-deoxy-10-deazapteroic acid; (S)-2-(4-(((2,4-Diamino-6-pteridinyl)methyl)amino)benzamido)pentanedioic acid
EINECS	Contact for details

Quality Control

Our 10-Deazaaminopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications and supporting your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.