Description

6-Mercaptopurine Riboside 5''-Phosphate Sodium is a nucleotide analog and a key intermediate in the synthesis of active metabolites for therapeutic applications. This compound matters for its critical role in biochemical research and pharmaceutical development, particularly in the study of purine metabolism and antimetabolite drug mechanisms. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for targeted therapies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active metabolites for antimetabolite and immunosuppressive drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to purine salvage pathways and nucleotide metabolism.
• Oncology Research: Investigated in the development and mechanism-of-action studies of chemotherapeutic agents targeting rapidly dividing cells.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Metabolite Studies: Employed in pharmacokinetic and metabolic profiling research to understand drug activation pathways.
• Enzyme Assay Development: Utilized in the design and optimization of assays for enzymes like inosine monophosphate dehydrogenase (IMPDH).

Basic Information

Product Name	6-Mercaptopurine Riboside 5''-Phosphate Sodium
CAS No.	52416-88-3
Molecular Formula	C11H14N4O7PSNa
Molecular Weight	408.28 g/mol
Synonyms	6-Thioinosinic Acid Sodium Salt; 6-Thio-IMP Sodium Salt; Sodium 6-Mercaptopurin-9-yl-ribofuranoside 5'-Phosphate; 6-MP Riboside 5'-Phosphate Sodium; Thioinosine Monophosphate Sodium Salt; 6-Thioinosine 5'-Monophosphate Sodium; NSC 4911 Sodium Salt; 6-MPRP Sodium
EINECS	Contact for details

Quality Control

Our 6-Mercaptopurine Riboside 5''-Phosphate Sodium is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.