Description

Ketotrexate CAS NO 52386-42-2 is a high-purity pharmaceutical intermediate and active ingredient of significant commercial and research importance. Its primary value lies in its role as a key building block for the synthesis of advanced pharmaceutical compounds, particularly in oncology and immunology research. This product is essential for manufacturers and research institutions engaged in the development and production of specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex active pharmaceutical ingredients (APIs) for targeted therapies.
• Oncology Research: Used in the development and study of novel chemotherapeutic agents and treatment protocols.
• Immunosuppressant Development: Serves as a key component in research for autoimmune disease and transplant rejection medications.
• Biochemical Research: Employed as a standard or reagent in enzymatic and metabolic pathway studies.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control testing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	Ketotrexate
CAS No.	52386-42-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ketotrexate; 52386-42-2; (S)-Ketotrexate; L-Ketotrexate; Ketotrexate Acid; Ketotrexate Intermediate; Anti-folate analog; DHFR inhibitor intermediate
EINECS	Contact for details

Quality Control

Our Ketotrexate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, to meet the stringent requirements of pharmaceutical development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under conditions of low humidity. For long-term storage, consider using a desiccator. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.