Description

3-(n-Acetyl-L-Cystein-S-Yl) Acetaminophen, Sodium Salt is a specialized biochemical derivative that combines the structural motifs of N-acetylcysteine (NAC) and acetaminophen (paracetamol). This compound is of significant interest in pharmaceutical research and development, particularly for its potential role in studying drug metabolism, detoxification pathways, and as a reference standard. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in advanced metabolic studies, biomarker research, and the development of novel therapeutic agents or diagnostic tools.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for the quantification and identification of metabolites in biological samples.
• Metabolic Pathway Research: Critical for in-vitro and in-vivo studies investigating the conjugation and detoxification pathways of acetaminophen, especially those involving glutathione and its precursors.
• Toxicology Studies: Employed in research focused on acetaminophen-induced hepatotoxicity and the protective mechanisms of thiol-based compounds like N-acetylcysteine.
• Biomarker Development: Serves as a key compound in the development and validation of analytical methods (e.g., LC-MS/MS) for detecting specific drug adducts and metabolic conjugates.
• Biochemical Reagent: Used in enzymatic and chemical studies related to cysteine and glutathione biochemistry.
• Drug Discovery & Development: A valuable intermediate or tool compound in medicinal chemistry programs aimed at designing new analgesics with improved safety profiles.

Basic Information

Product Name	3-(n-Acetyl-L-Cystein-S-Yl) Acetaminophen, Sodium Salt
CAS No.	52372-86-8
Molecular Formula	C13H15N2NaO5S
Molecular Weight	334.32 g/mol
Synonyms	N-Acetyl-S-(3-(acetylamino)-4-hydroxyphenyl)-L-cysteine Sodium Salt; APAP-NAC Sodium Salt; Paracetamol-NAC Conjugate Sodium Salt; 3-(N-Acetyl-L-cystein-S-yl)paracetamol Sodium Salt; N-Acetyl-S-(4-hydroxy-3-acetamidophenyl)cysteine Sodium Salt; Sodium 2-((R)-2-acetamido-3-((4-hydroxy-3-acetamidophenyl)thio)propanoate); Acetaminophen Cysteine Adduct Sodium Salt
EINECS	Contact for details

Quality Control

Our 3-(n-Acetyl-L-Cystein-S-Yl) Acetaminophen, Sodium Salt is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.