Description

Dipivefrine is a prodrug of epinephrine, specifically designed for enhanced ocular penetration in the treatment of glaucoma. This compound matters for its ability to effectively lower intraocular pressure with potentially fewer systemic side effects compared to its active metabolite. It is primarily needed by pharmaceutical manufacturers and R&D facilities in the ophthalmic sector for the formulation of advanced glaucoma medications.

Application

• Ophthalmic Drug Manufacturing: Primary active pharmaceutical ingredient (API) in prescription eye drops for the management of open-angle glaucoma and ocular hypertension.
• Pharmaceutical Research & Development: Key intermediate or reference standard in the development of new prodrug-based ophthalmic therapies and delivery systems.
• Analytical Chemistry: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Academic & Clinical Studies: Used in pharmacological research to study prodrug mechanisms, ocular pharmacokinetics, and comparative efficacy studies.

Basic Information

Product Name	Dipivefrine
CAS No.	52365-63-6
Molecular Formula	C19H29NO5
Molecular Weight	351.44 g/mol
Synonyms	Dipivalyl Epinephrine; Dipivefrin; Dipivalyl Adrenaline; DPE; 3,4-Di(pivaloyloxy)-α-[(methylamino)methyl]benzyl Alcohol; (±)-Dipivefrine; (±)-3,4-Di-O-pivaloylepinephrine; Propine (brand name reference)
EINECS	257-879-5

Quality Control

Our Dipivefrine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA), detailing identity, purity, and impurity profiles, is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.