Description

Monobutyryl Cyclic Gmp CAS NO 52246-50-1 is a chemically modified derivative of cyclic guanosine monophosphate (cGMP), a crucial secondary messenger in cellular signaling pathways. This butyryl-modified analog is specifically designed for enhanced membrane permeability and stability in biological research applications. It is primarily utilized by researchers and developers in the life sciences sector, particularly within pharmaceutical R&D and biochemical research, to study and modulate intracellular processes related to nitric oxide signaling, cardiovascular function, and neurological regulation.

Application

• Biochemical Research: As a cell-permeable cGMP analog for studying signal transduction pathways, protein kinase G (PKG) activation, and ion channel regulation.
• Pharmaceutical Development: A key reference standard and intermediate in the research and development of novel therapeutics targeting cardiovascular diseases, pulmonary hypertension, and erectile dysfunction.
• Cell Biology Studies: Used to investigate the role of cGMP in cellular processes such as smooth muscle relaxation, platelet aggregation inhibition, and neuronal plasticity.
• Enzyme Assays: Serves as a substrate or modulator in enzymatic assays for phosphodiesterases (PDEs) and guanylyl cyclases to screen for potential inhibitors or activators.
• Academic Research: A critical tool in university and institutional labs for fundamental research in molecular biology, physiology, and pharmacology.

Basic Information

Product Name	Monobutyryl Cyclic Gmp
CAS No.	52246-50-1
Molecular Formula	C14H18N5O8P
Molecular Weight	415.30 g/mol
Synonyms	N2-Butyryl-cGMP; 2'-Butyryl-cGMP; 2'-O-Butyryl-cGMP; Butyryl Cyclic GMP; cGMP, 2'-butyryl-; 2'-O-Butyryl-guanosine 3',5'-cyclic monophosphate; 2'-Butyryl-3',5'-cyclic GMP; 2'-O-Butyryl-3',5'-cyclic GMP; N2-Butyryl-cyclic GMP
EINECS	Contact for details

Quality Control

Our Monobutyryl Cyclic Gmp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.