Description

5,6,7,8-Tetrahydro-8-Deazafolic Acid is a key biochemical intermediate and structural analog of folic acid. This compound is of significant value in pharmaceutical research and development, particularly in the study of enzyme inhibition and metabolic pathways. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential chemotherapeutic agents and enzyme inhibitors.
• Biochemical Research: Used as a research tool to study folate metabolism, enzyme kinetics, and the mechanism of action of antifolate drugs.
• Enzyme Inhibition Studies: Acts as a reference compound or substrate analog in assays targeting dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for fundamental and applied life science research.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	5,6,7,8-Tetrahydro-8-Deazafolic Acid
CAS No.	51989-29-8
Molecular Formula	C₁₉H₂₁N₇O₆
Molecular Weight	443.42 g/mol
Synonyms	8-Deaza-5,6,7,8-tetrahydrofolic acid; 5,6,7,8-Tetrahydro-8-deazapteroylglutamic acid; THF-8-Deaza analog; NSC 154131; 8-Deazaaminopterin intermediate; Tetrahydro-8-deazafolate
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydro-8-Deazafolic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.