Description

3-Sn-Lysophosphatidyl-L-Serine is a crucial phospholipid derivative, specifically a lysophospholipid, where the glycerol backbone is esterified with a single fatty acid chain at the sn-1 position and a serine headgroup at the sn-3 position. This compound matters as a key signaling molecule and metabolic intermediate in cellular processes, particularly in the nervous and immune systems. It is essential for researchers and manufacturers in the pharmaceutical, nutraceutical, and life science sectors who require high-purity lipid standards, drug delivery components, or bioactive ingredients for advanced formulations.

Application

• Pharmaceutical Research & Development: Used as a reference standard, a precursor for synthesizing complex phospholipids, and in studying cell signaling pathways related to apoptosis and inflammation.
• Liposome & Drug Delivery Systems: Serves as a critical component in the formulation of liposomes and lipid nanoparticles (LNPs) for targeted drug delivery and mRNA vaccine technology.
• Biochemical & Cell Biology Studies: Employed in membrane biophysics research, enzyme assays (e.g., phospholipase studies), and as a tool to investigate receptor-ligand interactions.
• Nutraceutical & Cosmetic Formulations: Incorporated into advanced supplements and cosmetic products for its potential bioactive properties related to cognitive support and skin barrier function.
• Diagnostic Reagents: Utilized in the development of diagnostic kits and assays for detecting specific enzymes or metabolic disorders.

Basic Information

Product Name	3-Sn-Lysophosphatidyl-L-Serine
CAS No.	51826-99-4
Molecular Formula	C9H18NO8P (for the base structure; varies with fatty acid chain)
Molecular Weight	Contact for details (varies by fatty acid substituent)
Synonyms	1-Acyl-2-hydroxy-sn-glycero-3-phosphoserine; Lysophosphatidylserine; LPS; Lyso-PS; 1-Acyl-sn-glycero-3-phosphoserine; (2R)-2-Hydroxy-3-[(phosphonooxy)propyl] (9Z)-octadec-9-enoate (for 1-oleoyl variant); sn-3-Lysophosphatidyl-L-serine; O-Lysophosphatidylserine
EINECS	Contact for details

Quality Control

Our 3-Sn-Lysophosphatidyl-L-Serine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and cGMP manufacturing. Comprehensive Certificates of Analysis (COA) detailing purity, fatty acid profile, and residual solvent levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white powder or waxy solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Fatty Acid Composition	Specified per grade (e.g., 1-Palmitoyl, 1-Stearoyl, 1-Oleoyl)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.