Description

6-(Boc-Amino)Caproic Acid n-Succinimidyl Ester is a high-purity, heterobifunctional crosslinking reagent featuring a protected amine and an amine-reactive N-hydroxysuccinimide (NHS) ester. This compound is critical for the controlled synthesis of peptide conjugates, bioconjugates, and antibody-drug conjugates (ADCs), enabling the introduction of a stable, spacer-linked Boc-protected amine group. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require precise and reliable linker chemistry.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Linker Synthesis: Serves as a key intermediate for attaching cytotoxic drugs, fluorophores, or other payloads to antibodies or proteins via a stable amide bond and a cleavable spacer arm.
• Peptide Synthesis and Modification: Used to introduce a protected aminohexanoic acid (Ahx) spacer with a Boc-protected amine terminus into peptide chains during solid-phase or solution-phase synthesis.
• Surface Functionalization and Biomaterial Engineering: Facilitates the covalent immobilization of biomolecules onto nanoparticles, microarrays, or polymer surfaces for biosensor and diagnostic device development.
• Crosslinking Agent for Protein-Protein or Protein-Ligand Studies: Enables the study of protein interactions and complex formation in structural biology and drug discovery.
• Preparation of Affinity Chromatography Resins: Used to couple ligands to solid supports for the purification of specific proteins or antibodies.
• Polymer Chemistry: Acts as a monomer or modifier for creating functionalized polymers with pendant amine groups for further chemical reactions.

Basic Information

Item	Details
Product Name	6-(Boc-Amino)Caproic Acid n-Succinimidyl Ester
CAS No.	51513-80-5
Molecular Formula	C15H24N2O6
Molecular Weight	328.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-6-aminohexanoic Acid N-Hydroxysuccinimide Ester; Boc-6-Ahx-OSu; Boc-Ahx-OSu; N-Boc-6-aminohexanoic Acid Succinimidyl Ester; Nα-Boc-Nε-6-aminohexanoic Acid NHS Ester; (6-{[(2-Methylpropan-2-yl)oxy]carbonyl}amino)hexanoic Acid 2,5-Dioxopyrrolidin-1-yl Ester; Boc-6-Amino Caproic Acid NHS Ester; Boc-NH-(CH2)5-CO-OSu
EINECS	Contact for details

Quality Control

Our 6-(Boc-Amino)Caproic Acid n-Succinimidyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for identification. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile; slightly soluble in dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.