Description

N6,3'-o-Diacetyl-2'-Deoxyadenosine 5'-Monophosphate is a chemically modified nucleotide derivative, serving as a crucial building block and intermediate in advanced biochemical research and synthesis. Its primary value lies in enabling the study and development of oligonucleotides with specific modifications, impacting fields like molecular biology and therapeutic nucleic acid development. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and reliable nucleotide analogs for their work.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Research: Used in the development of therapeutic oligonucleotides with enhanced stability and targeting properties.
• Biochemical Probes: Acts as a substrate or intermediate for creating labeled nucleotides used in diagnostic assays and imaging.
• Enzymology Studies: Serves as a modified substrate to investigate the activity and specificity of kinases, polymerases, and other nucleic acid-metabolizing enzymes.
• Pharmaceutical Intermediates: A critical raw material in the research and development stages of novel nucleotide-based drugs.
• Academic & Industrial R&D: Fundamental material for exploring novel nucleic acid chemistries and applications in life sciences.

Basic Information

Product Name	N6,3'-o-Diacetyl-2'-Deoxyadenosine 5'-Monophosphate
CAS No.	51246-82-3
Molecular Formula	C₁₄H₁₈N₅O₈P
Molecular Weight	415.30 g/mol
Synonyms	2'-Deoxy-N6,3'-O-diacetyladenosine 5'-monophosphate; dA-3',N6-diacetyl-5'-monophosphate; 5'-Monophosphate of N6,3'-O-diacetyl-2'-deoxyadenosine; 2'-Deoxyadenosine, N6,3'-diacetyl-, 5'-(dihydrogen phosphate); Modified 2'-Deoxyadenosine Monophosphate; Acetylated dAMP Derivative; Nucleotide Synthesis Intermediate
EINECS	Contact for details

Quality Control

Our N6,3'-o-Diacetyl-2'-Deoxyadenosine 5'-Monophosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous in-house specifications aligned with industry best practices for fine chemicals and nucleotide derivatives.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.