Description

8-Bromoguanosine 3',5'-(Cyclic) Monophosphatesodium Salt n-Hydrate is a chemically modified nucleotide analog of cyclic guanosine monophosphate (cGMP). This compound is a crucial biochemical tool for studying cyclic nucleotide signaling pathways, particularly those involving cGMP-dependent protein kinases (PKG). It is primarily utilized by researchers in pharmaceutical R&D, academic biochemistry, and molecular biology laboratories for investigating cellular processes, enzyme kinetics, and as a potential precursor for novel therapeutic agents.

Application

• Biochemical Research: Acts as a stable, brominated analog of cGMP for probing the structure and function of phosphodiesterases (PDEs) and PKG enzymes.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and screening of drugs targeting cardiovascular and neurological disorders.
• Enzyme Kinetics Studies: Used to investigate substrate specificity, inhibition, and activation mechanisms of nucleotide-metabolizing enzymes.
• Cell Signaling Pathway Analysis: Employed in cellular assays to modulate and study cGMP-mediated signal transduction.
• Diagnostic Reagent Manufacturing: Can be incorporated into kits for research-grade diagnostic assays related to cyclic nucleotide levels.

Basic Information

Product Name	8-Bromoguanosine 3',5'-(Cyclic) Monophosphatesodium Salt n-Hydrate
CAS No.	51116-01-9
Molecular Formula	C10H11BrN5NaO7P · xH2O
Molecular Weight	Anhydrous: 438.09 g/mol
Synonyms	8-Br-cGMP sodium salt; Sodium 8-bromoguanosine 3',5'-cyclic monophosphate hydrate; 8-Bromo-cGMP Na salt; 8-Bromoguanosine cyclic 3',5'-(hydrogen phosphate) sodium salt; 8-Bromo-cyclic GMP sodium salt; 8-Br-cyclic GMP Na; 8-Bromoguanosine 3',5'-cyclic monophosphoric acid sodium salt
EINECS	Contact for details

Quality Control

Our 8-Bromoguanosine 3',5'-(Cyclic) Monophosphatesodium Salt n-Hydrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 10.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.