Description

(+)-1,4-Di-o-Tosyl-2,3-o-Isopropylidene-D-Threitol is a high-purity, chiral synthetic intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the preparation of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing stereochemically defined targets.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring specific D-threitol-derived stereochemistry.
• Asymmetric Synthesis: Used in the preparation of chiral ligands, catalysts, and auxiliaries for stereoselective transformations.
• Nucleoside & Carbohydrate Chemistry: Serves as a protected precursor in the synthesis of modified nucleosides, nucleotides, and complex sugar derivatives.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances where precise stereocontrol is essential.
• Agrochemical Research: Utilized as an intermediate in developing chiral active ingredients for crop protection agents.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	(+)-1,4-Di-o-Tosyl-2,3-o-Isopropylidene-D-Threitol
CAS No.	51064-65-4
Molecular Formula	C24H30O8S2
Molecular Weight	502.61 g/mol
Synonyms	D-Threitol, 1,4-di-O-tosyl-2,3-O-isopropylidene-; (2R,3R)-2,3-O-Isopropylidene-1,4-di-O-(p-tolylsulfonyl)threitol; 1,4-Di-O-tosyl-2,3-O-isopropylidene-D-threitol; 2,3-O-Isopropylidene-1,4-di-O-tosyl-D-threitol; (3aR,6aR)-2,2-Dimethyl-4,5-bis[(4-methylphenyl)sulfonyl]-tetrahydrofuro[3,4-d][1,3]dioxole
EINECS	Contact for details

Quality Control

Our (+)-1,4-Di-o-Tosyl-2,3-o-Isopropylidene-D-Threitol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.