Description

(+)-Homatropine CAS NO 51017-33-5 is a high-purity, enantiomerically pure form of the tropane alkaloid homatropine. This compound is a critical chiral intermediate and active pharmaceutical ingredient (API) valued for its antimuscarinic and mydriatic properties. It is essential for manufacturers in the pharmaceutical, research, and fine chemical sectors requiring precise stereochemistry for drug development and synthesis.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of ophthalmic solutions and cycloplegic/mydriatic agents for diagnostic eye examinations.
• Chiral Intermediate: Serves as a key building block in the asymmetric synthesis of more complex pharmaceutical compounds and bioactive molecules.
• Biochemical Research: Employed as a selective muscarinic acetylcholine receptor (mAChR) antagonist in pharmacological and neurological studies.
• Reference Standard: Utilized as a high-purity calibration standard in analytical laboratories for quality control and method development (HPLC, GC).
• Fine Chemical Synthesis: A precursor in the synthesis of specialty chemicals and derivatives for advanced material science applications.

Basic Information

Product Name	(+)-Homatropine
CAS No.	51017-33-5
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	D-Homatropine; (3S)-3-[(2S)-2-Hydroxy-2-phenylacetyl]oxy-8-methyl-8-azabicyclo[3.2.1]octane; Dextro-Homatropine; Homatropine (D-form); (+)-Tropyl mandelate; Mandelyltropine; Isopto Homatropine (component); Homatropine Hydrobromide precursor
EINECS	Contact for details

Quality Control

Our (+)-Homatropine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical and research use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.