Description

(-)-Homatropine CAS NO 51017-31-3 is the levorotatory enantiomer of homatropine, a tropane alkaloid derivative with significant pharmacological activity. This high-purity chiral building block is critical for research and development in stereoselective synthesis and for producing optically pure active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and advanced chemical synthesis laboratories focusing on neurology and ophthalmology.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of anticholinergic and mydriatic drugs.
• Research Chemical: Used in pharmacological studies to investigate muscarinic acetylcholine receptor antagonism and its stereospecific effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Asymmetric Synthesis: Employed as a chiral template or resolving agent in the preparation of enantiomerically enriched compounds.
• Ophthalmic Formulation R&D: Investigated for developing new cycloplegic and mydriatic agents with optimized activity profiles.

Basic Information

Product Name	(-)-Homatropine
CAS No.	51017-31-3
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	L-Homatropine; (-)-Tropyl mandelate; Levohomatropine; (3S)-3-[(2S)-2-Hydroxy-2-phenylacetyl]oxy-8-methyl-8-azabicyclo[3.2.1]octane; Mandelyltropeine; Homatropine levo-isomer
EINECS	Contact for details

Quality Control

Our (-)-Homatropine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (IR, NMR) are provided for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%, Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.