Description

Ac-Lys-Pna Hcl is a protected amino acid derivative, specifically an acetylated lysine para-nitroanilide hydrochloride salt, widely used as a key building block and research reagent. This compound is essential for the synthesis of peptides and the study of enzymatic processes, particularly those involving lysine-specific proteases. It is a critical material for pharmaceutical R&D, biochemical research, and the development of diagnostic assays. Its consistent quality and purity are paramount for ensuring reproducible experimental and manufacturing results.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the solid-phase and solution-phase synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a specific chromogenic substrate for the assay and characterization of lysine-specific proteases, such as trypsin and plasmin, in enzyme kinetics studies.
• Proteomics & Diagnostics: Employed in the development of diagnostic kits and assays for detecting and quantifying specific protease activity in biological samples.
• Chemical Biology: Acts as a tool compound for studying post-translational modifications, particularly acetylation, and their role in cellular signaling pathways.
• Academic & Industrial R&D: A fundamental reagent in university and corporate laboratories for investigating protein function, enzyme mechanisms, and novel therapeutic targets.

Basic Information

Product Name	Ac-Lys-Pna Hcl
CAS No.	50931-35-6
Molecular Formula	C14H21N5O4 • HCl
Molecular Weight	375.81 g/mol
Synonyms	Nα-Acetyl-L-lysine p-nitroanilide hydrochloride; Ac-Lys-pNA • HCl; L-Lysine, N2-acetyl-, 4-nitroanilide, hydrochloride; Acetyl-L-lysine-p-nitroanilide hydrochloride; N-Acetyl-L-lysine 4-nitroanilide hydrochloride; Protease Substrate (Lys-pNA); Trypsin Chromogenic Substrate; 50931-35-6
EINECS	Contact for details

Quality Control

Every batch of Ac-Lys-Pna Hcl is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and mass spectrometry is supplied with each shipment. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.