Description

Adenosine-8(3)H 3',5'-Cyclic Monophosphate is a tritium-labeled derivative of the vital intracellular second messenger, cyclic AMP (cAMP). This radiolabeled compound is essential for high-sensitivity research into cAMP-mediated signaling pathways, receptor activity, and enzyme kinetics. It is a critical tool for researchers and pharmaceutical developers in life sciences, particularly in drug discovery, biochemical assay development, and metabolic studies.

Application

• Biochemical Research & Assay Development: Used as a tracer in radioimmunoassays (RIA), enzyme immunoassays (EIA), and scintillation proximity assays (SPA) to quantify cAMP levels and study adenylate cyclase activity.
• Drug Discovery & Pharmacology: Enables the screening and characterization of novel compounds targeting G-protein-coupled receptors (GPCRs) and phosphodiesterases (PDEs) by measuring changes in intracellular cAMP.
• Cell Signaling Studies: Investigates the role of cAMP as a second messenger in cellular processes such as gene expression, metabolism, ion channel function, and apoptosis.
• Enzyme Kinetics & Metabolism: Serves as a substrate for studying the kinetics of enzymes like phosphodiesterases and protein kinase A (PKA).
• Diagnostic Kit Manufacturing: A key component in the production of in-vitro diagnostic kits for hormonal and metabolic disorders.

Basic Information

Product Name	Adenosine-8(3)H 3',5'-Cyclic Monophosphate
CAS No.	50816-76-7
Molecular Formula	C10H11N5O6P * (³H)
Molecular Weight	~330.21 g/mol (unlabeled)
Synonyms	8-³H-cAMP; Tritiated cAMP; Adenosine 3',5'-cyclic monophosphate, 8-(³H)-; Cyclic AMP, [8-³H]-; cAMP, tritium labeled; 8-Tritioadenosine 3',5'-cyclic phosphate; 8-(³H)Adenosine 3',5'-cyclic monophosphate; [8-³H]cAMP
EINECS	Contact for details

Quality Control

Every batch of our Adenosine-8(3)H 3',5'-Cyclic Monophosphate is manufactured and handled under strict quality protocols. The product undergoes rigorous analytical testing, including HPLC for radiochemical purity and identity confirmation, to ensure it meets the exacting standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing specific activity, purity, and solvent composition is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (-20°C or below) in the original solvent as supplied. For long-term storage, solutions are recommended to be kept at -70°C to minimize radiolytic decomposition. Always handle and store in accordance with local regulations for radioactive materials.

Specification

Item	Specification
Appearance	Clear solution
Specific Activity	20-40 Ci/mmol
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Identification (IR/Spectrometry)	Conforms to structure
Solvent	Ethanol: Water (Specified ratio)
Concentration	1 mCi/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.