Description

3-Azidopyridine-Adenine Dinucleotide is a chemically modified dinucleotide cofactor analog, specifically engineered for advanced biochemical research and development. This compound is critical for studying enzyme mechanisms, particularly those involving NAD(P)-dependent enzymes, through photoaffinity labeling and cross-linking techniques. It is an essential reagent for pharmaceutical researchers, enzymologists, and chemical biologists working in drug discovery, proteomics, and structural biology.

Application

• Photoaffinity Labeling Probe: Used to identify and characterize binding sites of NAD(P)-dependent enzymes, such as dehydrogenases and reductases.
• Enzyme Mechanism Studies: Enables the investigation of catalytic pathways and cofactor binding dynamics in biochemical research.
• Proteomic Target Identification: Facilitates the capture and isolation of protein targets in complex biological mixtures for drug discovery.
• Chemical Biology Tool Development: Serves as a key building block for creating novel chemical probes and activity-based protein profiling (ABPP) reagents.
• Structural Biology: Aids in X-ray crystallography and cryo-EM studies by providing a cross-linking handle for stabilizing enzyme-cofactor complexes.
• Bioconjugation and Biocatalysis: Used in the development of immobilized enzyme systems and novel biocatalytic pathways.

Basic Information

Product Name	3-Azidopyridine-Adenine Dinucleotide
CAS No.	50695-15-3
Molecular Formula	C21H26N10O14P2
Molecular Weight	728.44 g/mol
Synonyms	3-Azidopyridine adenine dinucleotide; 3-Azido-PAD; N6-(3-Azidopyridine)-adenine dinucleotide; Azido-NAD analog; Photoaffinity NAD analog; 3-Azidopyridine NAD+; 3-N3-PAD; Chemical probe for NAD-binding enzymes
EINECS	Contact for details

Quality Control

Our 3-Azidopyridine-Adenine Dinucleotide is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality systems support development under cGMP guidelines for investigational use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (UV-Vis)	≥ 90%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.