Description

10-Doxylstearic Acid is a spin-labeled derivative of stearic acid, incorporating a stable nitroxide radical (doxyl group) at the 10th carbon position. This compound is a crucial tool in biophysical and materials research, serving as a paramagnetic probe for studying molecular dynamics, membrane fluidity, and protein interactions using techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. It is essential for researchers and developers in the pharmaceutical, life sciences, and advanced materials sectors who require precise molecular reporters for structural and kinetic analysis.

Application

• As a spin label in Electron Paramagnetic Resonance (EPR) spectroscopy for studying lipid bilayer dynamics and membrane protein interactions.
• A paramagnetic probe for investigating membrane fluidity and phase transitions in model and biological membranes.
• Used in structural biology to analyze protein conformation, folding, and ligand binding sites via site-directed spin labeling (SDSL).
• Research applications in biophysics to measure molecular distances and conformational changes using double electron-electron resonance (DEER).
• As a standard or reference compound in the development and validation of analytical methods for nitroxide radicals.
• Potential use in the synthesis of advanced functional materials where controlled radical properties are required.

Basic Information

Product Name	10-Doxylstearic Acid
CAS No.	50613-98-4
Molecular Formula	C26H50NO4
Molecular Weight	440.68 g/mol
Synonyms	10-DOXYL Stearic Acid; 10-Doxyloctadecanoic Acid; 2-(10-Carboxydecyl)-2-hexyl-3,4-dihydro-2H-pyrrole 1-Oxide; 10-(3-Carboxypropyl)-10H-phenothiazine (incorrect but sometimes associated); 10-Stearic Acid Doxyl; EPR Probe 10-DSA; 10-DOXYL Labeled Stearic Acid; Nitroxide-labeled Stearic Acid
EINECS	Contact for details

Quality Control

Our 10-Doxylstearic Acid is manufactured under strict quality protocols to ensure high purity and consistent performance as a research-grade spin label. Each batch is characterized to confirm the identity and concentration of the active nitroxide radical. A comprehensive Certificate of Analysis (COA) is provided, detailing key parameters such as assay (by HPLC), radical purity, and specific tests for identity. We support compliance with relevant research and quality management standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize degradation of the nitroxide radical. The container should be kept in a dry, well-ventilated area away from sources of heat and incompatible materials. Allow the product to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystals
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Radical Purity (EPR)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.