Description

H-Ala-Ala-Ala-Pna Hcl is a high-purity tripeptide derivative, specifically the hydrochloride salt of H-Ala-Ala-Ala-Pna. This compound serves as a critical building block and biochemical tool in advanced research and development. It is primarily utilized by pharmaceutical and biotechnology companies for applications in proteomics, enzyme substrate studies, and peptide synthesis. The product, identified by CAS No. 50450-80-1, is manufactured to exacting standards to ensure consistent performance in sensitive applications.

Application

• Protease/Enzyme Substrate Research: Used as a specific chromogenic or fluorogenic substrate for studying the activity and kinetics of various proteolytic enzymes, including serine proteases.
• Biochemical Assay Development: Serves as a key component in the design and validation of high-throughput screening (HTS) assays for drug discovery targeting enzymatic pathways.
• Peptide Synthesis & Medicinal Chemistry: Acts as a protected peptide intermediate or a model compound for developing novel peptide-based therapeutics and diagnostic agents.
• Academic & Industrial R&D: Employed in basic research to investigate protein-protein interactions, signal transduction mechanisms, and cellular processes.
• Quality Control Reagent: Can be used as a reference standard or calibrant in analytical laboratories for method development and quality assurance of peptide products.

Basic Information

Product Name	H-Ala-Ala-Ala-Pna Hcl
CAS No.	50450-80-1
Molecular Formula	C18H26N6O5 • HCl
Molecular Weight	434.90 g/mol (for free base C18H26N6O5)
Synonyms	H-Ala-Ala-Ala-pNA HCl; L-Alanyl-L-alanyl-L-alanine 4-nitroanilide hydrochloride; Ala-Ala-Ala-pNA • HCl; Tri-L-alanine p-nitroanilide hydrochloride; N-[(2S)-1-[[(2S)-1-[[(2S)-2-Aminopropanoyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-4-nitrobenzenecarboxamide hydrochloride; Substrate for Proteases; 4-Nitroanilide of Tri-L-alanine HCl
EINECS	Contact for details

Quality Control

Our H-Ala-Ala-Ala-Pna Hcl is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and water content (KF) analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (Karl Fischer)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.